Jack R Harkema Selected Research

Silicon Dioxide (Silica)

2/2024	Crystalline silica-induced pulmonary inflammation and autoimmunity in mature adult NZBW/f1 mice: age-related sensitivity and impact of omega-3 fatty acid intervention.
1/2022	Comparative effects of human-equivalent low, moderate, and high dose oral prednisone intake on autoimmunity and glucocorticoid-related toxicity in a murine model of environmental-triggered lupus.
1/2021	Silica Induction of Diverse Inflammatory Proteome in Lungs of Lupus-Prone Mice Quelled by Dietary Docosahexaenoic Acid Supplementation.
1/2021	Rapid Induction of Pulmonary Inflammation, Autoimmune Gene Expression, and Ectopic Lymphoid Neogenesis Following Acute Silica Exposure in Lupus-Prone Mice.
1/2021	Omega-3 Polyunsaturated Fatty Acid Intervention Against Established Autoimmunity in a Murine Model of Toxicant-Triggered Lupus.
11/2020	Omega-3 fatty acid intake suppresses induction of diverse autoantibody repertoire by crystalline silica in lupus-prone mice.
1/2020	Influence of total western diet on docosahexaenoic acid suppression of silica-triggered lupus flaring in NZBWF1 mice.
12/2019	Lupus, Silica, and Dietary Omega-3 Fatty Acid Interventions.
1/2019	Docosahexaenoic Acid Consumption Impedes Early Interferon- and Chemokine-Related Gene Expression While Suppressing Silica-Triggered Flaring of Murine Lupus.
1/2019	Mapping of Dynamic Transcriptome Changes Associated With Silica-Triggered Autoimmune Pathogenesis in the Lupus-Prone NZBWF1 Mouse.

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Jack R Harkema Research Topics

Disease

57	Inflammation (Inflammations) 01/2024 - 01/2002
20	Metaplasia 04/2020 - 06/2002
18	Asthma (Bronchial Asthma) 03/2022 - 04/2003
14	Pneumonia (Pneumonitis) 02/2024 - 02/2002
14	Glomerulonephritis 02/2024 - 01/2015
10	Rhinitis 10/2020 - 01/2007
8	Lung Injury 01/2023 - 08/2010
8	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 01/2016
8	Necrosis 11/2020 - 01/2007
6	Hypertrophy 02/2024 - 03/2010
6	Hyperplasia 01/2023 - 10/2011
6	Fibrosis (Cirrhosis) 12/2022 - 02/2010
6	Allergic Rhinitis 12/2019 - 06/2002
6	Hypoxia (Hypoxemia) 01/2015 - 11/2008
5	Lung Diseases (Lung Disease) 01/2024 - 05/2004
4	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2021 - 01/2015
4	Neoplasms (Cancer) 01/2019 - 06/2007
3	Tertiary Lymphoid Structures 01/2021 - 01/2015
3	Body Weight (Weight, Body) 12/2016 - 08/2007
3	Fatty Liver 12/2016 - 06/2005
3	Insulin Resistance 01/2016 - 01/2014
3	Infections 11/2011 - 11/2006
2	Proteinuria 01/2023 - 01/2016
2	Chronic Bronchitis 04/2020 - 08/2004
2	Nephritis 01/2020 - 01/2019
2	Chronic Obstructive Pulmonary Disease (COPD) 01/2020 - 04/2008
2	Weight Loss (Weight Reduction) 01/2019 - 01/2016
2	Dyslipidemias (Dyslipidemia) 01/2018 - 12/2011
2	Disease Progression 11/2017 - 08/2010
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2017 - 01/2014
2	Non-alcoholic Fatty Liver Disease 12/2016 - 12/2016
2	Atherosclerosis 10/2014 - 06/2004
2	Cystic Fibrosis (Mucoviscidosis) 04/2013 - 05/2004
2	Eosinophilia 03/2012 - 04/2010
2	Human Influenza (Influenza) 11/2011 - 03/2008
1	Hematuria 01/2023

Drug/Important Bio-Agent (IBA)

26	OzoneIBA 01/2023 - 01/2002
19	CytokinesIBA 01/2024 - 04/2003
14	Silicon Dioxide (Silica)FDA LinkGeneric 02/2024 - 01/2015
14	Particulate MatterIBA 03/2022 - 08/2004
12	Proteins (Proteins, Gene)FDA Link 11/2022 - 07/2008
10	Air Pollutants (Pollutants, Air)IBA 03/2022 - 05/2010
9	AutoantibodiesIBA 02/2024 - 01/2018
9	Polychlorinated Dibenzodioxins (TCDD)IBA 08/2021 - 06/2005
8	AllergensIBA 03/2014 - 02/2004
7	ChemokinesIBA 02/2024 - 01/2019
7	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2023 - 01/2018
6	Docosahexaenoic AcidsIBA 01/2024 - 01/2018
6	LipopolysaccharidesIBA 01/2023 - 08/2007
6	Messenger RNA (mRNA)IBA 12/2021 - 06/2004
6	Immunoglobulin E (IgE)IBA 04/2020 - 07/2003
6	Oxygen (Dioxygen)IBA 05/2018 - 11/2008
5	AerosolsIBA 01/2023 - 06/2003
5	EndotoxinsIBA 03/2014 - 01/2002
4	Immunoglobulin G (IgG)IBA 02/2024 - 01/2015
4	SootIBA 01/2023 - 01/2020
4	CollagenIBA 12/2022 - 12/2016
4	Environmental Pollutants (Pollutants, Environmental)IBA 03/2022 - 08/2004
4	Oxidants (Oxidizing Agents)IBA 10/2021 - 10/2007
4	InterferonsIBA 01/2021 - 01/2020
4	DNA (Deoxyribonucleic Acid)IBA 01/2017 - 02/2004
4	OvalbuminIBA 03/2012 - 04/2003
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2012 - 02/2002
3	Interleukin-13IBA 11/2020 - 04/2008
3	SmogIBA 01/2017 - 02/2011
3	Glucose (Dextrose)FDA LinkGeneric 12/2016 - 01/2014
3	Interleukin-6 (Interleukin 6)IBA 12/2016 - 02/2007
3	Interleukin-5 (Interleukin 5)IBA 03/2016 - 06/2004
3	LipidsIBA 12/2015 - 01/2014
3	Transcription Factors (Transcription Factor)IBA 01/2015 - 11/2008
3	CobaltIBA 02/2014 - 02/2010
3	Alanine Transaminase (SGPT)IBA 10/2013 - 12/2011
3	MycotoxinsIBA 07/2008 - 11/2006
2	CarbonIBA 10/2021 - 12/2016
2	RNA (Ribonucleic Acid)IBA 01/2021 - 01/2020
2	Hydroxyproline (4 Hydroxyproline)IBA 11/2020 - 11/2017
2	ethyleneIBA 10/2020 - 11/2015
2	Insulin (Novolin)FDA Link 01/2016 - 01/2014
2	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 12/2015 - 12/2011
2	Therapeutic UsesIBA 03/2014 - 10/2007
2	AntioxidantsIBA 03/2014 - 10/2007
2	satratoxin GIBA 08/2012 - 07/2006
2	Cannabinoid Receptors (Cannabinoid Receptor)IBA 11/2011 - 03/2008
2	2,4,5,2',4',5'-hexachlorobiphenylIBA 10/2011 - 03/2010
2	SmokeIBA 08/2010 - 06/2009
2	Phenobarbital (Luminal)FDA Link 04/2010 - 08/2004
2	ChitinasesIBA 02/2010 - 04/2008
2	MucinsIBA 11/2009 - 04/2008
2	gamma-TocopherolIBA 06/2009 - 10/2007
2	trichotheceneIBA 08/2007 - 11/2006
2	trimellitic anhydrideIBA 07/2006 - 06/2004
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 02/2024
1	LuciferasesIBA 01/2024
1	Urea (Carbamide)FDA LinkGeneric 01/2023
1	Epoxide HydrolasesIBA 01/2023
1	NitrogenIBA 01/2023
1	Bleomycin (Blenoxane)FDA LinkGeneric 12/2022
1	Prednisolone (Predate)FDA LinkGeneric 12/2022
1	nintedanibIBA 12/2022

Therapy/Procedure

4	Therapeutics 04/2008 - 05/2004